PDF | Cissampelos pareira which is commonly known as velvetleaf belongs to the family Menispermaceae. Numbers of species are available all over the world . Cissampelos pareira f. emarginato-mucronata Chod. & Hassl. Synonym. Cissampelos pareira f. reniformis Chodat & Hassl. Synonym. Cissampelos pareira var. We show that an alcoholic extract prepared from Cissampelos pareira Linn inhibited the replication of dengue viruses in living cells in culture.

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Cissampelos pareira – Wikipedia

The healing power of rainforest csisampelos. Effect of Cipa extract on erythrocytes and platelets ex vivo and in vivo For ex vivo studies, human blood was collected from healthy adult donors after informed consent. Organ weights in Cipa extract-treated Wistar rats. Dengue and dengue haemorrhagic fever.

Cissampelos pareira

Ten years of dengue drug discovery: The type-1 assay was designed to identify herbal extracts that had the ability to block DENV from entering susceptible cells. At the end of the experiment, the survival data was used to plot Kaplan Meier survival curves and analysed pareura the log rank test Mantel-Cox test for statistical significance using GraphPad Prism 5 software.

Plants and preparation of extracts Plants shortlisted for screening are indicated in Table 1. The mice were monitored daily for mortality and the resultant data plotted as Kaplan-Meier survival curves.


Flowers are small in size, pedicels filiform. Symptomatic dengue illness can range from mild dengue fever DF to severe and potentially fatal dengue haemorrhagic fever DHF and dengue shock syndrome DSS [ 4 ]. Another herb — Cyclea peltata is also used in the name of Patha. The current map showing distribution of species is only indicative. This essentially corroborates an earlier report that the Cipa extract is essentially non-toxic and well tolerated in the animal model [ 29 ].

To this end, extracts were prepared from Cipa plants collected during different seasons from multiple geographical locations within India. The resultant methanol-free Cipa paste was thoroughly re-suspended in 0.

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Cissampelos pareira Illustration Credit: Male flowers clustered in the axil of a small leaf; sepals are 4 in number, obovate-oblong, hairy outside; petals 4 in number, united to form a 4-toothed cup, hairy outside; stamens 4, column short, anthers connate, encircling the top of the column.

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Cissampelos pareira L. | Species | India Biodiversity Portal

It is indigenous to the Amazon rain forest but also grows abundantly in India. Natural History Natural History.

B Wistar rats were orally administered 0. Vascular plant diversity in the sacred grove of Modapalli in Viskhapatnam District of Andhra Pradesh, There are four serotypes of dengue viruses DENV-1, -2, -3 and -4belonging to the family Flaviviridae [ 1 ], which are prevalent in more than a hundred mosquito-infested countries in the tropical and sub-tropical regions of the globe [ cissampeloss3 ].


Acknowledgments The authors acknowledge Prof. The effect of Cipa extract on platelets was also cisszmpelos in an in vivo experiment using Wistar rats. A total of species belo In addition, a preliminary LC-MS analysis of extracts from two different locations S1 Figdemonstrates that the two Cipa extracts manifest essentially similar profiles.

A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.

In the control sample, blood mixed with pareida salineplatelet counts declined steadily over time. The survival data are present in Fig 4. Flowers minute, pedicels filiform. In this experiment, platelet counts were determined in blood drawn from rats which had been given Cipa extract orally. Dengue Day 1 Test. To assess any potential cytotoxicity, cells were exposed to the herbal extracts in the same cissampeloos range in the absence of DENV infection.

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